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| Cat.No | ACP23581 | Target Name | NOP2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P46087 |
|---|
Uniprot Id
P46087
Target Species
Human
Target Name
NOP2
Target Full Name
28S rRNA (cytosine(4447)-C(5))-methyltransferase
Target Function
Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable).
Target Subcellular Location
Nucleus, nucleolus.
Target Protein Families
Class I-like SAM-binding methyltransferase superfamily, RsmB/NOP family
Target Synonyms
NOP2; NOL1; NSUN1Probable 28S rRNA; cytosine(4447)-C(5))-methyltransferase; EC 2.1.1.-; Nucleolar protein 1; Nucleolar protein 2 homolog; Proliferating-cell nucleolar antigen p120; Proliferation-associated nucleolar protein p120
Target Background
Enables RNA binding activity. Involved in positive regulation of cell population proliferation; regulation of signal transduction by p53 class mediator; and ribosomal large subunit assembly. Located in nucleolus.
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