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| Cat.No | ACP10541 | Target Name | ALKBH4 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 2-302 | Protein Length | Full Length of Mature Protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NXW9 |
|---|
Uniprot Id
Q9NXW9
Target Species
Human
Target Name
ALKBH4
Target Full Name
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4
Target Function
Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing.
Target Subcellular Location
Cytoplasm. Nucleus. Nucleus, nucleolus. Midbody.
Target Protein Families
AlkB family
Target Tissue Specificity
Widely expressed, with highest expression in pancreas, ovary and spleen.
Target Synonyms
2010004B12Rik; ABH4; Abj4; AlkB; alkylation repair homolog 4 (E. coli); ALKB4_HUMAN; Alkbh4; Alkylated DNA repair protein alkB homolog 4; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4; FLJ20013; Probable alpha-ketoglutarate dependent dioxygenase ABH4; RGD1308608
Target Background
Enables 2-oxoglutarate-dependent dioxygenase activity and actin binding activity. Involved in actomyosin structure organization; cleavage furrow ingression; and protein demethylation. Located in contractile ring and midbody.
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