Recombinant Human Probable ATP-dependent RNA helicase DDX46 (DDX46), Truncated

Uniprot Id

Q7L014

Target Species

Human

Target Name

DDX46

Target Full Name

Probable ATP-dependent RNA helicase DDX46

Target Function

Plays an essential role in splicing, either prior to, or during splicing A complex formation.

Target Subcellular Location

Nucleus speckle. Nucleus, Cajal body. Membrane; Lipid-anchor. Note=Present in Cajal bodies (CBs) and nuclear speckles.

Target Protein Families

DEAD box helicase family, DDX46/PRP5 subfamily

Target Synonyms

DDX46; KIAA0801Probable ATP-dependent RNA helicase DDX46; EC 3.6.4.13; DEAD box protein 46; PRP5 homolog

Target Background

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing. Multiple alternatively spliced transcript variants have been found for this gene.