Recombinant Human Probable E3 ubiquitin-protein ligase RNF144A (RNF144A), Truncated

Uniprot Id

P50876

Target Species

Human

Target Name

RNF144A

Target Full Name

E3 ubiquitin-protein ligase RNF144A

Target Function

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC.

Target Subcellular Location

Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle membrane.

Target Protein Families

RBR family, RNF144 subfamily

Target Synonyms

RNF144A; KIAA0161; RNF144; UBCE7IP4; E3 ubiquitin-protein ligase RNF144A; RING finger protein 144A; UbcM4-interacting protein 4; Ubiquitin-conjugating enzyme 7-interacting protein 4

Target Background

This gene encodes a member of a family of RING finger domain-containing E3 ubiquitin ligases that also includes parkin and parc. The expression of this gene is induced by DNA damage. The encoded protein interacts with the cytoplasmic DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) and promotes its degradation through ubiquitination. The orthologous mouse protein has been shown to interact with a ubiquitin-conjugating enzyme involved in embryonic development.