Recombinant Human Probable phospholipid-transporting ATPase IH (ATP11A), Truncated

Uniprot Id

P98196

Target Species

Human

Target Name

ATP11A

Target Full Name

Phospholipid-transporting ATPase IH

Target Function

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane. Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation. May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Target Protein Families

Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily

Target Tissue Specificity

Widely expressed. Expressed in myoblasts.

Target Synonyms

AT11A; AT11A_HUMAN; Atp11a; ATPase class VI type 11A; ATPase IS; ATPIH; ATPIS; P4-ATPase flippase complex alpha subunit ATP11A; Probable phospholipid-transporting ATPase IH