Recombinant Human Probable serine protease HTRA3 (HTRA3)

Uniprot Id

P83110

Target Species

Human

Target Name

HTRA3

Target Full Name

Serine protease HTRA3

Target Function

Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization.

Target Subcellular Location

Secreted. Note=Secretion increased during decidualization of endometrial stromal cells.

Target Protein Families

Peptidase S1C family

Target Tissue Specificity

Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle,

Target Synonyms

High temperature requirement factor A3; High-temperature requirement factor A3; HtrA serine peptidase 3; HTRA3; HTRA3_HUMAN; Pregnancy related serine protease; Pregnancy-related serine protease; Probable serine protease HTRA3; PRSP ; Serine protease HTRA3; Tasp

Target Background

Enables endopeptidase activity; identical protein binding activity; and serine-type peptidase activity. Involved in proteolysis. Predicted to be located in extracellular region.