Recombinant Human Protein-arginine deiminase type-1 (PADI1)

Uniprot Id

Q9ULC6

Target Species

Human

Target Name

PADI1

Target Full Name

Protein-arginine deiminase type-1

Target Function

Catalyzes the deimination of arginine residues of proteins.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Protein arginine deiminase family

Target Tissue Specificity

Detected in epidermal keratinocytes (at protein level). Epidermis, prostate, testis, placenta, spleen and thymus.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

HPAD10; Padi1; PADI1_HUMAN; PDI; PDI1; Peptidylarginine deiminase I; protein arginine deiminase type I; Protein-arginine deiminase type I; Protein-arginine deiminase type-1

Target Background

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes.