Recombinant Human Protein Dr1 (DR1)

Uniprot Id

Q01658

Target Species

Human

Target Name

DR1

Target Full Name

Protein Dr1

Target Function

The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Target Subcellular Location

Nucleus.

Target Protein Families

NC2 beta/DR1 family

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

Down regulator of transcription 1; Down regulator of transcription 1 TBP binding; Down-regulator of transcription 1; down-regulator of transcription 1; TBP-binding (negative cofactor 2); DR 1; Dr1; Dr1 protein; NC 2; NC2; NC2 beta; NC2-beta; NC2B_HUMAN; Negative co factor 2; Negative cofactor 2; Negative cofactor 2 beta; Negative cofactor 2-beta; Protein Dr1; TATA binding protein associated phosphoprotein; TATA box/binding protein associated phosphoprotein DR1; TATA-binding protein-associated phosphoprotein

Target Background

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.