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| Cat.No | ACP12865 | Target Name | FAM111A |
|---|---|---|---|
| Target Synonyms | FAM111A; KIAA1895Protein FAM111A | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-611 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96PZ2 |
|---|
Uniprot Id
Q96PZ2
Target Species
Human
Target Name
FAM111A
Target Full Name
Serine protease FAM111A
Target Function
Single-stranded DNA-binding serine protease that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Protects replication fork from stalling by removing DPCs, such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesion, or poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors. Required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis.; (Microbial infection) May directly function at replication forks, explaining why Simian virus 40 (SV40) interacts with FAM111A to overcome host range restriction.
Target Involvement
Kenny-Caffey syndrome 2 (KCS2); Gracile bone dysplasia (GCLEB)
Target Subcellular Location
Nucleus. Chromosome. Cytoplasm.
Target Protein Families
FAM111 family
Target Synonyms
FAM111A; KIAA1895Protein FAM111A
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