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| Cat.No | ACP12682 | Target Name | NSMAF |
|---|---|---|---|
| Target Synonyms | NSMAF; FANProtein FAN; Factor associated with neutral sphingomyelinase activation; Factor associated with N-SMase activation | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q92636 |
|---|
Uniprot Id
Q92636
Target Species
Human
Target Name
NSMAF
Target Full Name
Protein FAN
Target Function
Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.
Target Tissue Specificity
Ubiquitous.
Target Synonyms
NSMAF; FANProtein FAN; Factor associated with neutral sphingomyelinase activation; Factor associated with N-SMase activation
Target Background
This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.
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