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| Cat.No | ACP08058 | Target Name | JAGN1 |
|---|---|---|---|
| Target Synonyms | JAGN1; Protein jagunal homolog 1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N5M9 |
|---|
Uniprot Id
Q8N5M9
Target Species
Human
Target Name
JAGN1
Target Full Name
Protein jagunal homolog 1
Target Function
Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils.
Target Involvement
Neutropenia, severe congenital 6, autosomal recessive (SCN6)
Target Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Protein Families
Jagunal family
Target Tissue Specificity
Ubiquitously expressed.
Target Synonyms
JAGN1; Protein jagunal homolog 1
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