Recombinant Human Protein kinase C-binding protein 1 (ZMYND8), Truncated

Uniprot Id

Q9ULU4

Target Species

Human

Target Name

ZMYND8

Target Full Name

MYND-type zinc finger-containing chromatin reader ZMYND8

Target Function

May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion.

Target Subcellular Location

Nucleus. Cytoplasm.

Target Tissue Specificity

Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta. Expressed in cutaneous T-cell lymphomas (CTCL).

Target Synonyms

ZMYND8; KIAA1125; PRKCBP1; RACK7; Protein kinase C-binding protein 1; Cutaneous T-cell lymphoma-associated antigen se14-3; CTCL-associated antigen se14-3; Rack7; Zinc finger MYND domain-containing protein 8

Target Background

The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene.