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| Cat.No | ACP09644 | Target Name | SBNO2 |
|---|---|---|---|
| Target Synonyms | SBNO2; KIAA0963Protein strawberry notch homolog 2 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9Y2G9 |
|---|
Uniprot Id
Q9Y2G9
Target Species
Human
Target Name
SBNO2
Target Full Name
Protein strawberry notch homolog 2
Target Function
Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation. Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the proinflammatory cascade.
Target Protein Families
SBNO family
Target Tissue Specificity
Detected in macrophages. IL10 regulates expression in a STAT3-dependent way.
Target Synonyms
SBNO2; KIAA0963Protein strawberry notch homolog 2
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