Recombinant Human Protein tyrosine phosphatase type IVA 2 (PTP4A2)

Uniprot Id

Q12974

Target Species

Human

Target Name

PTP4A2

Target Full Name

Protein tyrosine phosphatase type IVA 2

Target Function

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.

Target Subcellular Location

Cell membrane. Early endosome. Cytoplasm.

Target Protein Families

Protein-tyrosine phosphatase family

Target Tissue Specificity

Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue.

Target Synonyms

PTP4A2; PRL2; PTPCAAX2; BM-008; Protein tyrosine phosphatase type IVA 2; EC 3.1.3.48; HU-PP-1; OV-1; PTP(CAAXII); Protein-tyrosine phosphatase 4a2; Protein-tyrosine phosphatase of regenerating liver 2; PRL-2

Target Background

The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17.