Recombinant Human Protein unc-119 homolog A (UNC119)

Uniprot Id

Q13432

Target Species

Human

Target Name

UNC119

Target Full Name

Protein unc-119 homolog A

Target Function

Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A

Target Involvement

Immunodeficiency 13 (IMD13)

Target Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle.

Target Protein Families

PDE6D/unc-119 family

Target Tissue Specificity

Abundantly expressed in retina, in photoreceptor synapses and inner segments. Expressed in a much lesser extent in several other tissues.

Target Research Area

Neuroscience

Target Synonyms

Cone-rod dystrophy, included; hRG4; Human retinal gene 4; MRG4; POC7; POC7 centriolar protein homolog A; POC7A; Protein unc 119 homolog A; Protein unc-119 homolog A; Retinal protein 4; RG4; RRG4; Rtg4; U119A_HUMAN; unc 119 homolog (C. elegans); Unc 119 protein homolog; unc119 (C.elegans) homolog; UNC119; Unc119h; Uncl19