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The recombinant Human SFTPB protein is encoded by the gene of SFTPB (201-279aa). The gene of SFTPB was cloned in a system (Yeast) that supported the expression of SFTPB. Modification of SFTPB by recombinant DNA technology could lead to the expression of the target protein. The purity is 90% determined by SDS-PAGE.SFTPB is a protein coding gene that encodes Pulmonary surfactant-associated protein B. According to some studies, SFTPB may have the following features. The genetic relationship between lung surfactant protein genes SFTPA1, SFTPA2, SFTPB, SFTPC and SFTPD and cystic fibrosis. Mutations in the thyroid transcription factor gene NKX2-1 resulted in decreased expression of SFTPB and SFTPC. The pattern in the CA repeat-rich region of surfactant protein B (SFTPB) intron 4 has different effects on mRNA splicing. Analyze 40 cases of sporadic or familial neonatal and pediatric severe unexplained respiratory distress. The relationship with SFTPB. SFTPB gene lineage evolutionary event. Alu recombination-mediated deletion (ARMD), exonization and alternative splicing events. The upregulation of Sftpb induced by estrogen requires the transcriptional control of the neuroglutenin receptor ErbB4 in mouse lung type II epithelial cells.
The recombinant Human SFTPB protein is encoded by the gene of SFTPB (201-279aa). The gene of SFTPB was cloned in a system (Yeast) that supported the expression of SFTPB. Modification of SFTPB by recombinant DNA technology could lead to the expression of the target protein. The purity is 90% determined by SDS-PAGE.SFTPB is a protein coding gene that encodes Pulmonary surfactant-associated protein B. According to some studies, SFTPB may have the following features. The genetic relationship between lung surfactant protein genes SFTPA1, SFTPA2, SFTPB, SFTPC and SFTPD and cystic fibrosis. Mutations in the thyroid transcription factor gene NKX2-1 resulted in decreased expression of SFTPB and SFTPC. The pattern in the CA repeat-rich region of surfactant protein B (SFTPB) intron 4 has different effects on mRNA splicing. Analyze 40 cases of sporadic or familial neonatal and pediatric severe unexplained respiratory distress. The relationship with SFTPB. SFTPB gene lineage evolutionary event. Alu recombination-mediated deletion (ARMD), exonization and alternative splicing events. The upregulation of Sftpb induced by estrogen requires the transcriptional control of the neuroglutenin receptor ErbB4 in mouse lung type II epithelial cells.
| Cat.No | ACP04723 | Target Name | SFTPB |
|---|---|---|---|
| Target Synonyms | SFTPB; SFTP3; Pulmonary surfactant-associated protein B; SP-B; 18 kDa pulmonary-surfactant protein; 6 kDa protein; Pulmonary surfactant-associated proteolipid SPL(Phe | Form | Liquid or Lyophilized powder |
| Expression System | Yeast | Expression Range | 201-279aa |
| Mol Weight | 8.7kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P07988 |
|---|
Uniprot Id
P07988
Target Species
Human
Target Name
SFTPB
Target Full Name
Pulmonary surfactant-associated protein B
Target Function
Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
Target Involvement
Pulmonary surfactant metabolism dysfunction 1 (SMDP1); Respiratory distress syndrome in premature infants (RDS)
Target Subcellular Location
Secreted, extracellular space, surface film.
Target Research Area
Cell Biology, Cardiovascular
Target Synonyms
SFTPB; SFTP3; Pulmonary surfactant-associated protein B; SP-B; 18 kDa pulmonary-surfactant protein; 6 kDa protein; Pulmonary surfactant-associated proteolipid SPL(Phe
Target Background
This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.
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