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| Cat.No | ACP13982 | Target Name | UBR7 |
|---|---|---|---|
| Target Synonyms | UBR7; C14orf130; Putative E3 ubiquitin-protein ligase UBR7; EC 2.3.2.27; N-recognin-7; RING-type E3 ubiquitin transferase UBR7 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-425 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N806 |
|---|
Uniprot Id
Q8N806
Target Species
Human
Target Name
UBR7
Target Full Name
Putative E3 ubiquitin-protein ligase UBR7
Target Function
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Target Tissue Specificity
Expressed in sperm (at protein level).
Target Synonyms
UBR7; C14orf130; Putative E3 ubiquitin-protein ligase UBR7; EC 2.3.2.27; N-recognin-7; RING-type E3 ubiquitin transferase UBR7
Target Background
This gene encodes a UBR box-containing protein that belongs to the E3 ubiquitin ligase family. The protein also contains a plant homeodomain (PHD) in the C-terminus. In mammals, the encoded protein recognizes N-degrons, the destabilizing N-terminal residues of short-lived proteins, which results in ubiquitinylation, and proteolysis via the proteasome.
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