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| Cat.No | ACP03478 | Target Name | PDXK |
|---|---|---|---|
| Target Synonyms | ; Vitamin B6 kinase, pdxK; PDXK_HUMAN; PKH; PNK ; Pyridoxal kinase; Pyridoxamine kinase; Pyridoxine kinase; Pyridoxine kinase | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-312aa |
| Mol Weight | 62.1kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O00764 |
|---|
Uniprot Id
O00764
Target Species
Human
Target Name
PDXK
Target Full Name
Pyridoxal kinase
Target Function
Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (Probable). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions.
Target Subcellular Location
Cytoplasm, cytosol.
Target Protein Families
Pyridoxine kinase family
Target Tissue Specificity
Ubiquitous. Highly expressed in testis.; [Isoform 3]: In adult testis and spermatozoa.
Target Research Area
Signal Transduction
Target Synonyms
pdxK; PDXK_HUMAN; PKH; PNK ; Pyridoxal kinase; Pyridoxamine kinase; Pyridoxine kinase; Pyridoxine kinase,; Vitamin B6 kinase
Target Background
The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
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