Recombinant Human Ras-related protein Rab-26 (RAB26)

Uniprot Id

Q9ULW5

Target Species

Human

Target Name

RAB26

Target Full Name

Ras-related protein Rab-26

Target Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.

Target Subcellular Location

Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle membrane; Lipid-anchor; Cytoplasmic side.

Target Protein Families

Small GTPase superfamily, Rab family

Target Tissue Specificity

Predominantly expressed in brain.

Target Synonyms

CATX-8; RAB11c; Rab26; RAB26 member RAS oncogene family; RAB26_HUMAN; Ras related oncogene protein; Ras related protein Rab 26; Ras-associated protein Rab26; Ras-related protein Rab-26; V46133

Target Background

Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]).