Recombinant Human Regulator of G-protein signaling 9 (RGS9)

Uniprot Id

O75916

Target Species

Human

Target Name

RGS9

Target Full Name

Regulator of G-protein signaling 9

Target Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction.

Target Involvement

Prolonged electroretinal response suppression (PERRS)

Target Subcellular Location

[Isoform 3]: Membrane; Peripheral membrane protein.

Target Tissue Specificity

Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and ret

Target Synonyms

PERRS; R9AP; Regulator of G protein signalling 9; Regulator of G-protein signaling 9; RGS9; RGS9_HUMAN; RGS9L

Target Background

This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.