Recombinant Human Regulator of telomere elongation helicase 1 (RTEL1), Truncated

Uniprot Id

Q9NZ71

Target Species

Human

Target Name

RTEL1

Target Full Name

Regulator of telomere elongation helicase 1

Target Function

ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.

Target Involvement

Dyskeratosis congenita, autosomal recessive, 5 (DKCB5); Dyskeratosis congenita, autosomal dominant, 4 (DKCA4); Pulmonary fibrosis, and/or bone marrow failure, telomere-related, 3 (PFBMFT3)

Target Subcellular Location

Nucleus.

Target Protein Families

Helicase family, RAD3/XPD subfamily

Target Synonyms

RTEL1; C20orf41; KIAA1088; NHLRegulator of telomere elongation helicase 1; EC 3.6.4.12; Novel helicase-like