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| Cat.No | ACP01857 | Target Name | RNASET2 |
|---|---|---|---|
| Target Synonyms | Ribonuclease 6 | Form | Liquid or Lyophilized powder |
| Expression System | Yeast | Expression Range | 25-256aa |
| Mol Weight | 30.9 kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O00584 |
|---|
Uniprot Id
O00584
Target Species
Human
Target Name
RNASET2
Target Full Name
Ribonuclease T2
Target Function
Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. Plays also a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs.
Target Involvement
Leukoencephalopathy, cystic, without megalencephaly (LCWM)
Target Subcellular Location
Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Mitochondrion intermembrane space.
Target Protein Families
RNase T2 family
Target Tissue Specificity
Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.
Target Research Area
Cancer
Target Synonyms
bA514O12.3; Ribonuclease 6; Ribonuclease T2; RNASE6PL; Rnaset2; RNT2_HUMAN; RP11 514O12.3
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