Recombinant Human RNA-binding protein MEX3B (MEX3B)

Uniprot Id

Q6ZN04

Target Species

Human

Target Name

MEX3B

Target Full Name

RNA-binding protein MEX3B

Target Function

RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.

Target Subcellular Location

Nucleus. Cytoplasm. Cytoplasm, P-body. Cytoplasmic granule. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3.

Target Tissue Specificity

Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level.

Target Synonyms

MEX3B; KIAA2009; RKHD3; RNF195RNA-binding protein MEX3B; RING finger and KH domain-containing protein 3; RING finger protein 195

Target Background

This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies.