Recombinant Human RNA-binding protein Musashi homolog 2 (MSI2)

Uniprot Id

Q96DH6

Target Species

Human

Target Name

MSI2

Target Full Name

RNA-binding protein Musashi homolog 2

Target Function

RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system.

Target Involvement

Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23).

Target Subcellular Location

Cytoplasm.

Target Protein Families

Musashi family

Target Tissue Specificity

Ubiquitous; detected at low levels.

Target Synonyms

FLJ36569; MGC3245; Msi2; MSI2/HOXA9 fusion gene, included; MSI2H; MSI2H_HUMAN; Musashi 2; Musashi homolog 2; Musashi RNA binding protein 2; Musashi, Drosophila, homolog of, 2; Musashi-2; RNA binding protein Musashi homolog 2; RNA-binding protein Musashi homolog 2; WD 40 repeat protein MSI2

Target Background

This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells.