Recombinant Human RNA methyltransferase-like protein 1 (RNMTL1)

Uniprot Id

Q9HC36

Target Species

Human

Target Name

MRM3

Target Full Name

rRNA methyltransferase 3, mitochondrial

Target Function

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

Target Subcellular Location

Mitochondrion.

Target Protein Families

Class IV-like SAM-binding methyltransferase superfamily, RNA methyltransferase TrmH family

Target Tissue Specificity

Expressed at same level in normal liver and hepatocarcinoma.

Target Synonyms

16S rRNA (guanosine(1370)-2'-O)-methyltransferase; 16S rRNA [Gm1370] 2'-O-methyltransferase; 4833420N02Rik; AI255153; FLJ10581; HC90; MRM3; MRM3_HUMAN; Putative RNA methyltransferase; RMTL1; RNA methyltransferase like 1; RNA methyltransferase like protein 1; RNA methyltransferase-like protein 1; RP23-147P4.7; rRNA methyltransferase 3, mitochondrial

Target Background

Efficient translation of mitochondrial-derived transcripts requires proper assembly of the large subunit of the mitochondrial ribosome. Central to the biogenesis of this large subunit is the A-loop of mitochondrial 16S rRNA, which is modified by three rRNA methyltransferases located near mtDNA nucleoids. The protein encoded by this gene methylates G(1370) of 16S rRNA, and this modification is necessary for proper ribosomal large subnit assembly. Two transcript variants encoding different isoforms have been found for this gene.