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| Cat.No | ACP24435 | Target Name | SLFN14 |
|---|---|---|---|
| Target Synonyms | Schlafen family member 14; SLFN14; SLN14_HUMAN | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P0C7P3 |
|---|
Uniprot Id
P0C7P3
Target Species
Human
Target Name
SLFN14
Target Full Name
Protein SLFN14
Target Function
Shows no ribosome-associated and endoribonuclease activities.; Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs. May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs. Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner. Involved in correct maturation of megakaryocytes and especially important for proplatelet extension.
Target Involvement
Bleeding disorder, platelet-type 20 (BDPLT20)
Target Subcellular Location
[Protein SLFN14]: Nucleus.
Target Protein Families
Schlafen family
Target Tissue Specificity
Expressed in megakaryocytes and platelets (at protein level). Weakly expressed in melanocytes and malignant melanoma cells.
Target Synonyms
Schlafen family member 14; SLFN14; SLN14_HUMAN
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