Recombinant Human SCY1-like protein 2 (SCYL2), Truncated

Uniprot Id

Q6P3W7

Target Species

Human

Target Name

SCYL2

Target Full Name

SCY1-like protein 2

Target Function

Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system. A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed. By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development.

Target Subcellular Location

Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network membrane. Endosome membrane.

Target Protein Families

Protein kinase superfamily

Target Synonyms

AU015688; AW536445; BC030932; Coated vesicle-associated kinase of 104 kDa; CVAK104; D10Ertd802e; FLJ10074; KIAA1360; RGD1305665; SCY1 like 2 (S. cerevisiae); SCY1 like protein 2; SCY1-like protein 2; SCYL2; SCYL2_HUMAN

Target Background

The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene.