Recombinant Human SEC23-interacting protein (SEC23IP), Truncated

Uniprot Id

Q9Y6Y8

Target Species

Human

Target Name

SEC23IP

Target Full Name

SEC23-interacting protein

Target Function

Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P).

Target Subcellular Location

Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum.

Target Protein Families

PA-PLA1 family

Target Tissue Specificity

Ubiquitously expressed with stronger levels detected in heart, liver and skeletal muscle.

Target Synonyms

MSTP053; p125; P125A; Phospholipase; S23IP_HUMAN; Sec23 interacting protein p125; SEC23-interacting protein; SEC23IP

Target Background

This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development, suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced transcript variants have been observed for this gene.