Recombinant Human Semaphorin-3A (SEMA3A)

Uniprot Id

Q14563

Target Species

Human

Target Name

SEMA3A

Target Full Name

Semaphorin-3A

Target Function

Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.

Target Involvement

Hypogonadotropic hypogonadism 16 with or without anosmia (HH16)

Target Subcellular Location

Secreted.

Target Protein Families

Semaphorin family

Target Tissue Specificity

Expressed in the dorsal root ganglia.

Target Synonyms

SEMA3A; SEMAD; Semaphorin-3A; Semaphorin III; Sema III

Target Background

This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.