Recombinant Human Serine palmitoyltransferase 2 (SPTLC2), Truncated

Cat.No	ACP03940	Target Name	SPTLC2
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	88-562aa	Mol Weight	69.7kDa
Protein Length	Partial	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP03940

Target Name

SPTLC2

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

88-562aa

Mol Weight

69.7kDa

Protein Length

Partial

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	O15270

Background Information

Uniprot Id

O15270
Target Species

Human
Target Name

SPTLC2
Target Full Name

Serine palmitoyltransferase 2
Target Function

Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate. Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis.
Target Involvement

Neuropathy, hereditary sensory and autonomic, 1C (HSAN1C)
Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein.
Target Protein Families

Class-II pyridoxal-phosphate-dependent aminotransferase family
Target Tissue Specificity

Widely expressed.
Target Research Area

Cancer
Target Synonyms

KIAA0526; LCB 2; LCB2; LCB2a; Long chain base biosynthesis protein 2; Long chain base biosynthesis protein 2a; Serine palmitoyl CoA transferase 2; Serine palmitoyltransferase 2; Serine palmitoyltransferase long chain base subunit 2; Serine palmitoyltransferase subunit II; Serine-palmitoyl-CoA transferase 2; SPT 2; SPT2; SPTC2_HUMAN; SPTLC 2; Sptlc2
Target Background

This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I.

Recombinant Human Serine palmitoyltransferase 2 (SPTLC2), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Serine palmitoyltransferase 2 (SPTLC2), Truncated Now

Related Products