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| Cat.No | ACP10239 | Target Name | PPP4R2 |
|---|---|---|---|
| Target Synonyms | BE691708; C230060M08Rik; MGC131930 ; PP4R2; PP4R2_HUMAN; PPP4R2; protein phosphatase 4, regulatory subunit 2; Serine/threonine protein phosphatase 4 regulatory subunit 2; Serine/threonine-protein phosphatase 4 regulatory subunit 2 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-417 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NY27 |
|---|
Uniprot Id
Q9NY27
Target Species
Human
Target Name
PPP4R2
Target Full Name
Serine/threonine-protein phosphatase 4 regulatory subunit 2
Target Function
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.
Target Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2.
Target Protein Families
PPP4R2 family
Target Tissue Specificity
Widely expressed.
Target Synonyms
BE691708; C230060M08Rik; MGC131930 ; PP4R2; PP4R2_HUMAN; PPP4R2; protein phosphatase 4, regulatory subunit 2; Serine/threonine protein phosphatase 4 regulatory subunit 2; Serine/threonine-protein phosphatase 4 regulatory subunit 2
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