Recombinant Human Serum paraoxonase/arylesterase 2 (PON2)

Uniprot Id

Q15165

Target Species

Human

Target Name

PON2

Target Full Name

Serum paraoxonase/arylesterase 2

Target Function

Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.

Target Subcellular Location

Membrane; Peripheral membrane protein.

Target Protein Families

Paraoxonase family

Target Tissue Specificity

Widely expressed with highest expression in liver, lung, placenta, testis and heart.

Target Synonyms

A esterase 2 ; A-esterase 2; Aromatic esterase 2; Paraoxonase 2; Paraoxonase nirs; PON 2; PON2; PON2_HUMAN; Serum aryldialkylphosphatase 2; Serum paraoxonase/arylesterase 2

Target Background

This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.