Recombinant Human SH3 and cysteine-rich domain-containing protein (STAC)

Uniprot Id

Q99469

Target Species

Human

Target Name

STAC

Target Full Name

SH3 and cysteine-rich domain-containing protein

Target Function

Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.

Target Subcellular Location

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.

Target Synonyms

FLJ32331; SH3 and cysteine rich domain; SH3 and cysteine rich domain containing protein; SH3 and cysteine-rich domain-containing protein; SRC homology 3 and cysteine rich domain protein; Src homology 3 and cysteine-rich domain-containing protein; Src homology three (SH3) and cysteine rich domain; STAC 1; STAC; STAC_HUMAN; STAC1

Target Background

Predicted to enable transmembrane transporter binding activity. Predicted to be involved in positive regulation of protein localization to plasma membrane; positive regulation of voltage-gated calcium channel activity; and skeletal muscle contraction. Predicted to act upstream of or within cellular response to heat; muscle contraction; and regulation of voltage-gated calcium channel activity. Predicted to be located in T-tubule. Predicted to be extrinsic component of cytoplasmic side of plasma membrane.