Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
| Cat.No | ACP17284 | Target Name | SGO2 |
|---|---|---|---|
| Target Synonyms | Sgo2; Sgol2; SGOL2_HUMAN; Shugoshin-2; Shugoshin-like 2; Tripin | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q562F6 |
|---|
Uniprot Id
Q562F6
Target Species
Human
Target Name
SGO2
Target Full Name
Shugoshin 2
Target Function
Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase.
Target Subcellular Location
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.
Target Protein Families
Shugoshin family
Target Synonyms
Sgo2; Sgol2; SGOL2_HUMAN; Shugoshin-2; Shugoshin-like 2; Tripin
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
