Recombinant Human Sialic acid-binding Ig-like lectin 7 (SIGLEC7), Truncated

Cat.No	ACP09788	Target Name	SIGLEC7
Target Synonyms	Adhesion inhibitory receptor molecule 1; Adhesion inhibitory receptor molecule 1	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP09788

Target Name

SIGLEC7

Target Synonyms

Adhesion inhibitory receptor molecule 1; Adhesion inhibitory receptor molecule 1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9Y286

Background Information

Uniprot Id

Q9Y286
Target Species

Human
Target Name

SIGLEC7
Target Full Name

Sialic acid-binding Ig-like lectin 7
Target Function

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Target Subcellular Location

Membrane; Single-pass type I membrane protein.
Target Protein Families

Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
Target Tissue Specificity

Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
Target Synonyms

Adhesion inhibitory receptor molecule 1; Adhesion inhibitory receptor molecule 1, siglec 7; AIRM 1; AIRM-1; AIRM1; CD328; CD328 antigen; CDw328; D siglec; D-siglec; HLDA 8; p75; p75/AIRM1; QA79; QA79 membrane protein; Sialic acid binding Ig like lectin 7; Sialic acid binding immunoglobulin like lectin 7; Sialic acid-binding Ig-like lectin 7; SIGL7_HUMAN; Siglec-7; SIGLEC19P; SIGLEC7; SIGLECP2
Target Background

Predicted to enable sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane.

Recombinant Human Sialic acid-binding Ig-like lectin 7 (SIGLEC7), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Sialic acid-binding Ig-like lectin 7 (SIGLEC7), Truncated Now

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