Recombinant Human Sialic acid-binding Ig-like lectin 8 (SIGLEC8), Truncated

Uniprot Id

Q9NYZ4

Target Species

Human

Target Name

SIGLEC8

Target Full Name

Sialic acid-binding Ig-like lectin 8

Target Function

Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes.

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family

Target Tissue Specificity

Expressed specifically on red blood cells namely basophil, mast cells and eosinophils.

Target Synonyms

CD329 antigen; CDw329; SAF 2; SAF-2; SAF2; Sialic acid binding Ig like lectin 8; Sialic acid-binding Ig-like lectin 8; Sialoadhesin family member 2; SIGL8_HUMAN; Siglec 8; Siglec-8; SIGLEC8; SIGLEC8L

Target Background

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).