Recombinant Human Signal recognition particle 54 kDa protein (SRP54)

Uniprot Id

P61011

Target Species

Human

Target Name

SRP54

Target Full Name

Signal recognition particle subunit SRP54

Target Function

Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.

Target Subcellular Location

Nucleus speckle. Cytoplasm. Endoplasmic reticulum.

Target Protein Families

GTP-binding SRP family, SRP54 subfamily

Target Research Area

Signal Transduction

Target Synonyms

Signal recognition particle 54 kDa protein; Signal recognition particle 54kDa; SRP 54; SRP54; SRP54_HUMAN

Target Background

Enables several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and guanyl ribonucleotide binding activity. Contributes to GTPase activity. Involved in granulocyte differentiation and protein targeting to ER. Located in cytosol and nucleus. Part of signal recognition particle, endoplasmic reticulum targeting. Implicated in severe congenital neutropenia 8.