Home Products Recombinant Human Single-minded homolog 2 (SIM2)), Truncated

Recombinant Human Single-minded homolog 2 (SIM2)), Truncated

ACP00551

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Specifications

Cat.No	ACP00551	Target Name	SIM2
Target Synonyms	Class E basic helix-loop-helix protein 15;bHLHe15	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	342-525aa
Mol Weight	27.4 kDa	Protein Length	Partial
Purity	Greater than 95% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q14190

Background Information

Uniprot Id

Q14190
Target Species

Human
Target Name

SIM2
Target Full Name

Single-minded homolog 2
Target Function

Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.
Target Subcellular Location

Nucleus.
Target Research Area

Cancer
Target Synonyms

bHLHe15; Class E basic helix loop helix protein 15; Class E basic helix-loop-helix protein 15; MGC119447; SIM 2; SIM; Sim2; SIM2_HUMAN; Single minded homolog 2 (Drosophila); Single minded homolog 2; Single-minded homolog 2; Transcription factor SIM2
Target Background

This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants.

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Recombinant Human Single-minded homolog 2 (SIM2)), Truncated

Specifications

Immunogen Information

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