Recombinant Human SLIT and NTRK-like protein 6 (SLITRK6), Truncated

Uniprot Id

Q9H5Y7

Target Species

Human

Target Name

SLITRK6

Target Full Name

SLIT and NTRK-like protein 6

Target Function

Regulator of neurite outgrowth required for normal hearing and vision.

Target Involvement

Deafness and myopia (DFNMYP)

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Protein Families

SLITRK family

Target Tissue Specificity

In adult brain, highly expressed in putamen with no expression in cerebral cortex. Expressed in adult and fetal lung and fetal liver. Also expressed at high levels in some brain tumors including medulloblastomas and primitive neuroectodermal tumors.

Target Synonyms

4832410J21Rik; DFNMYP; MGC119595; MGC119596; MGC119597; OTTHUMP00000066012; SLIK6_HUMAN; SLIT and NTRK like family member 6; SLIT and NTRK like protein 6; SLIT and NTRK-like protein 6; Slit and trk like 6; Slit and trk like gene 6; SLITRK 6; Slitrk6

Target Background

This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. This protein functions as a regulator of neurite outgrowth required for normal hearing and vision. Mutations in this gene are a cause of myopia and deafness.