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| Cat.No | ACP21137 | Target Name | SGSM2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O43147 |
|---|
Uniprot Id
O43147
Target Species
Human
Target Name
SGSM2
Target Full Name
Small G protein signaling modulator 2
Target Function
Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation.
Target Subcellular Location
Cytoplasm. Melanosome.
Target Protein Families
RUTBC family
Target Tissue Specificity
Widely expressed.
Target Synonyms
D630003G22Rik; KIAA0397; mKIAA0397; R74628; RP23-174M12.3; RUN and TBC1 domain containing 1; RUN and TBC1 domain-containing protein 1; RUTBC1; Sgsm2; SGSM2_HUMAN; Small G protein signaling modulator 2; Small G protein signaling modulator 2 protein
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