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Recombinant Human SPRY domain-containing SOCS box protein 1 (SPSB1)

ACP12940

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Specifications

Cat.No	ACP12940	Target Name	SPSB1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-273	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q96BD6

Background Information

Uniprot Id

Q96BD6
Target Species

Human
Target Name

SPSB1
Target Full Name

SPRY domain-containing SOCS box protein 1
Target Function

Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5.
Target Subcellular Location

Cytoplasm. Cytoplasm, cytosol.
Target Protein Families

SPSB family
Target Research Area

Others
Target Synonyms

1110014L01Rik; 4930422J18Rik; AI596360; AI854583; MGC102221; novel SPRY domain containing protein; OTTHUMP00000001398; OTTMUSP00000010942; OTTMUSP00000010943; OTTMUSP00000023475; RGD1309319; RP23-169H13.1; RP3-324M8.1; splA/ryanodine receptor domain and SOCS box containing 1; SPRY domain containing SOCS box protein SSB 1; SPRY domain-containing SOCS box protein 1; SPSB1; SPSB1_HUMAN; SSB 1; SSB-1; SSB1
Target Background

Enables ubiquitin ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol.

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Recombinant Human SPRY domain-containing SOCS box protein 1 (SPSB1)

Specifications

Immunogen Information

Inquire Recombinant Human SPRY domain-containing SOCS box protein 1 (SPSB1) Now

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