Recombinant Human Synaptic vesicle membrane protein VAT-1 homolog (VAT1)

Uniprot Id

Q99536

Target Species

Human

Target Name

VAT1

Target Full Name

Synaptic vesicle membrane protein VAT-1 homolog

Target Function

Possesses ATPase activity. Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2).

Target Subcellular Location

Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein.

Target Protein Families

Zinc-containing alcohol dehydrogenase family, Quinone oxidoreductase subfamily

Target Tissue Specificity

Expressed in brain. Also expressed in glioblastoma cells.

Target Synonyms

VAT1; FLJ20230; Membrane protein of cholinergic synaptic vesicles; MGC124668; OTTMUSP00000002784; RP23-328K2.5; Synaptic vesicle membrane protein VAT 1 homolog; Synaptic vesicle membrane protein VAT-1 homolog; VAT 1; VAT1; VAT1_HUMAN; VATI; Vesicle amine transport protein 1; Vesicle amine transport protein 1 homolog (T. californica)

Target Background

Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins.