Recombinant Human T-box brain protein 1 (TBR1)

Uniprot Id

Q16650

Target Species

Human

Target Name

TBR1

Target Full Name

T-box brain protein 1

Target Function

Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection. As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons.

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Brain.

Target Synonyms

T box brain 1; T box brain protein 1; T brain 1 protein; T-box brain protein 1; T-brain-1; TBR 1; TBR-1; Tbr1; TBR1_HUMAN; TES 56; TES-56

Target Background

This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase.