Recombinant Human TATA box-binding protein-associated factor RNA polymerase I subunit C (TAF1C), Truncated

Uniprot Id

Q15572

Target Species

Human

Target Name

TAF1C

Target Full Name

TATA box-binding protein-associated factor RNA polymerase I subunit C

Target Function

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.

Target Subcellular Location

Nucleus.

Target Synonyms

RNA polymerase I-specific TBP-associated factor 110 kDa; SL1; Taf1c; TAF1C_HUMAN; TAFI110; TAFI95; TATA box binding protein associated factor 1C; TATA box-binding protein-associated factor 1C; TATA box-binding protein-associated factor RNA polymerase I subunit C; TBP associated factor 1C; TBP associated factor RNA polymerase I 95 kDa; TBP associated factor; RNA polymerase I; 110-KD; TBP-associated factor 1C; Transcription initiation factor SL1/TIF-IB subunit C

Target Background

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.