Recombinant Human TATA box-binding protein-like protein 1 (TBPL1)

Uniprot Id

P62380

Target Species

Human

Target Name

TBPL1

Target Full Name

TATA box-binding protein-like 1

Target Function

Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

TBP family

Target Tissue Specificity

Ubiquitously expressed, with highest levels in the testis and ovary.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

21 kDa TBP-like protein; 21kDa TBP like protein; Second TBP of unique DNA; Second TBP of unique DNA protein; STUD; TATA box binding protein like protein 1; TATA box binding protein-related factor 2; TATA box-binding protein-like protein 1; TATA box-binding protein-related factor 2; TBP like 1; TBP like protein; TBP related factor 2; TBP-like factor; TBP-like protein 1; TBP-related factor 2; TBP-related protein; tbpl1; TBPL1_HUMAN; TLF; TLP; TRF2

Target Background

This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3.