Recombinant Human Thyroid peroxidase (TPO), Truncated, Escherichia Coli

Uniprot Id

P07202

Target Species

Human

Target Name

TPO

Target Full Name

Thyroid peroxidase

Target Function

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).

Target Involvement

Thyroid dyshormonogenesis 2A (TDH2A)

Target Subcellular Location

Membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell surface.

Target Protein Families

Peroxidase family, XPO subfamily

Target Research Area

Cancer

Target Synonyms

MSA ; PERT_HUMAN; TDH2A; Thyroid microsomal antigen; Thyroid peroxidase; Thyroperoxidase; TPO; TPX

Target Background

This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.