Recombinant Human Transaldolase (TALDO1), Truncated

Uniprot Id

P37837

Target Species

Human

Target Name

TALDO1

Target Full Name

Transaldolase

Target Function

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

Target Involvement

Transaldolase deficiency (TALDOD)

Target Subcellular Location

Cytoplasm.

Target Protein Families

Transaldolase family, Type 1 subfamily

Target Research Area

Metabolism

Target Synonyms

Dihydroxyacetone transferase; EC 2.2.1.2; EPS8L2 ; Glycerone transferase ; TAL; TAL H; TALDO; TALDO_HUMAN; TALDO1; TALDOR ; TALH ; Transaldolase 1; Transaldolase

Target Background

Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis.