Recombinant Human Transcription elongation factor A protein 1 (TCEA1)

Uniprot Id

P23193

Target Species

Human

Target Name

TCEA1

Target Full Name

Transcription elongation factor A protein 1

Target Function

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.

Target Involvement

A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.

Target Subcellular Location

Nucleus.

Target Protein Families

TFS-II family

Target Synonyms

GTF2S; SII; TCEA; Tcea1; TCEA1_HUMAN; TF2S; TFIIS; Transcription elongation factor A (SII) 1; Transcription elongation factor A protein 1; Transcription elongation factor A, 1; Transcription elongation factor S-II protein 1; Transcription elongation factor TFIIS.o

Target Background

Predicted to enable DNA binding activity; translation elongation factor activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within erythrocyte differentiation and positive regulation of transcription, DNA-templated. Located in nucleolus and nucleoplasm. Part of transcription factor TFIID complex.