Recombinant Human Transcription elongation factor SPT6 (SUPT6H), Truncated

Uniprot Id

Q7KZ85

Target Species

Human

Target Name

SUPT6H

Target Full Name

Transcription elongation factor SPT6

Target Function

Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A

Target Subcellular Location

Nucleus.

Target Protein Families

SPT6 family

Target Tissue Specificity

Ubiquitously expressed.

Target Synonyms

emb 5; hSPT6; KIAA0162; MGC87943; SPT6H; SPT6H_HUMAN; Suppressor of Ty (S.cerevisiae) 6 homolog; Suppressor of Ty 6 homolog (S. cerevisiae); SUPT6H; Tat cotransactivator 2 protein; Tat CT2 protein; Tat-cotransactivator 2 protein; Tat-CT2 protein; Transcription elongation factor SPT6