Recombinant Human Transcription elongation regulator 1 (TCERG1), Truncated

Uniprot Id

O14776

Target Species

Human

Target Name

TCERG1

Target Full Name

Transcription elongation regulator 1

Target Function

Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Detected in brain neurons.

Target Synonyms

CA 150; Co activator of 150 kDa; Coactivator of 150 kDa; MGC133200; TAF 2S; TAF2S; TATA box binding protein (TBP) associated factor RNA polymerase II S 150kD; TATA box binding protein associated factor 2S; TATA box binding protein associated factor RNA polymerase II S 150kD; TATA box-binding protein-associated factor 2S; TBP-associated factor, RNA polymerase II, 150-kD; TCERG 1; TCERG1; TCRG1_HUMAN; Transcription elongation regulator 1; Transcription factor CA 150; Transcription factor CA150; Urn1

Target Background

This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.